The 2023 initiative by the US Army Medical Research and Development Command (MRDC) and Medical Technology Enterprise Consortium (MTEC) has renewed its efforts from previous projects while bringing original ideas and the latest technologies to the research. The goal is to bring measurable acceleration to clinical products through robust partnerships.
Abstracts
The abstracts and projects listed below are sponsored by the US Government under MTEC Research Project Award: MTEC-23-04-AFIRM-004. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon.
Lyophilized Platelet Surrogate for Traumatic Brain Injury-Associated Coagulopathy
Principal Investigator: Susan M. Shea, PhD; Co-PI Matthew D. Neal, MDOrganization: University of Pittsburgh Combat-associated traumatic hemorrhage is implicated in approximately 90% of preventable deaths in the prehospital …
Bioengineered Functional Craniomaxillofacial Alveolar Bone and Tooth Constructs
Principal Investigator: Pamela C. Yelick, PhDOrganization: Tufts University Craniomaxillofacial (CMF) injuries represented 33% of the battlefield injuries sustained in Operation Iraqi Freedom/Operation Enduring Freedom (Afghanistan)1, and 25% of …
Stem Cell Secretome-Based Recombinant Protein Therapy for Treatment of Acute Kidney Injury
Principal Investigator: John D. Jackson, PhD; Co-PI Ji Hyun Kim, PhDOrganization: Wake Forest Institute for Regenerative Medicine Acute kidney injury (AKI) is seen at a significantly high incidence …
Biofabrication of Surface-functionalized, Thin Membranes for Vascularized Bone Tissue Engineering Repair of CMF Trauma
Principal Investigator: David Dean, PhDOrganization: The Ohio State University Craniomaxillofacial (CMF) trauma may result in a gap in the bones making up the braincase or the face. These …
Tissue Engineering Functional Human Lips
Principal Investigator: Stephen E. Feinberg, DDS, MS, PhD; Co-PI Mary-Ann Mycek, PhDOrganization: Regents of the University of Michigan Our novel approach to reconstruct composite lip defects utilizes a …
Nerve Regeneration and Muscle Integration: A Tissue Engineering Strategy to Accelerate Nerve Regeneration and Maximize Muscle Function Restoration
Principal Investigator: Anthony J. Windebank, MDOrganization: Mayo Clinic Americans incur over 300,000 nerve injuries annually. Nerve injury leads to lost of limb function and oftentimes is accompanied by …
Tension-based strategy for graft-free peripheral nerve reconstruction
Principal Investigator: Sameer B. Shah, PhDPerforming Organization: University of California, San Diego Vehicular trauma and blast injuries are common causes of damage to the extremities of military personnel, …
Targeting the Endotheliopathy of Trauma (EOT) with Lyophilized Mesenchymal Stem Cells (MSCs) and Lyophilized MSC Extracellular Vesicles (EVs)
Principal Investigator: Shibani Pati, MD, PhDOrganization: University of California San Francisco The main goal of this project is to develop and test dried stem cell products (lyophilized-MSCs and …
Human Amnion Membrane Product (hAMP) for Treatment of Burn Wounds in Remote, Pre-hospital Setting
Principal Investigators: Shay Soker, PhD; Co-PI Sean Murphy, PhDOrganization: Wake Forest University Health Sciences Given the unpredictable future battle and casualty management environment, with definitive burn treatment occurring …
Acellular Muscle Fiber Fragment Platform for Rapid Recovery of Pelvic Floor Muscle Function
Principal Investigator: Ji Hyun Kim, PhDOrganization: Wake Forest Institute for Regenerative Medicine Pelvic and urogenital injuries account for 86% of urologic injuries in US armed conflicts, impacting the …
Rapid Recovery of Rotator Ruff Muscle Function using Decellularized Muscle Fiber Fragments as an off-the-shelf Injection Therapy
Principal Investigator: James J. Yoo, MD, PhD Organization: Wake Forest Institute for Regenerative Medicine Rotator cuff injuries or tears have a significant impact on both civilian and military …
Reprogramming Subject Skin to Palmo-Plantar Skin at the Distal Limb to Enhance Prosthetic use in Wounded Warriors
Principal Investigator: Luis Garza, MD, PhDPerforming Organization: Johns Hopkins University Background: Stem cell therapy holds great promise in medicine. This grant will employ one’s own stem cells in …
Proof of Concept Clinical Trial of Burns: Inhibiting Scar Formation and Promoting Skin Regeneration using a Topical Focal Adhesion Kinase Inhibitor (FAKI)
Burn injuries are among the most devastating of all injuries and a major global public health burden. Severe (full- and deep partial-thickness) burns are a significant challenge among …
Modular Lego-Like Scaffolds for In-theater Craniofacial Regeneration
Recent advancements in 3D printing have revolutionized the field of tissue engineering, particularly in the creation of tailored scaffolds for tissue regeneration. However, widespread adoption of this technology …
Clinical Therapies
The team will focus on developing clinical therapies over the next 5 years in the areas of:
Craniofacial Regeneration
Extremity Regeneration
Genitourinary/ Lower Abdomen
Skin and Wound Healing
On-Demand Blood
