The 2023 initiative by the US Army Medical Research and Development Command (MRDC) and Medical Technology Enterprise Consortium (MTEC) has renewed its efforts from previous projects while bringing original ideas and the latest technologies to the research. The goal is to bring measurable acceleration to clinical products through robust partnerships.
Abstracts
The abstracts and projects listed below are sponsored by the US Government under MTEC Research Project Award: MTEC-23-04-AFIRM-004. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon.
Autologous Point-of-Care Adipose Therapy for Reconstruction and Regeneration of Traumatized Skin
Principal Investigator: Francesco Egro, MBChB, MSc, MRCS, University of Pittsburgh
4-Aminopyridine for Wound and Burn Regenerative Therapy
Principle Investigator: John Elfar, MD, FACS, University of Arizona
On-Demand Anatomical Regeneration to Accelerate Return to Duty
Principal Investigator: LTC(R) Luis M. Alvarez, PhD, Theradaptive, Inc.
Minimally Invasive Post-Traumatic Craniofacial Soft Tissue Regeneration
Principal Investigator: J. Peter Rubin, MD, FACS, University of Pittsburgh
Prospective, First-in-Human Study of the NuCress™ Bone Void Filler for Localized Alveolar Ridge Augmentation
Principal Investigator: Jeffry Skiba, NuShores Biosciences LLC
Clinical Evaluation of a Novel Therapeutic to Prevent Distal Nerve Degeneration and Muscle Atrophy in Acute Nerve Injury
Principle Investigator: Seth Schulman, MD, Neuraptive Therapeutics, Inc.
Allogenic Adipose Derived Mesenchymal Stromal Cells (MSC) for Acute Kidney Injury after Trauma or Burn
Principle Investigator: Charles S. Cox, MD, University of Texas Health Science Center at Houston
A Phase 2a, Open-label, Safety, Tolerability, and Pharmacokinetics of a Single Dose of cP12 in Otherwise Healthy Adults with Up To and Including 5% Total Body Surface Area (TBSA) Thermal Burns
Principal Investigator: Richard Clark, MD, NeoMatrix Therapeutics
Lyophilized Platelet Surrogate for Traumatic Brain Injury-Associated Coagulopathy
Principal Investigator: Susan M. Shea, PhD; Co-PI Matthew D. Neal, MD, University of Pittsburgh
Bioengineered Functional Craniomaxillofacial Alveolar Bone and Tooth Constructs
Principal Investigator: Pamela Yelick, PhD, Tufts University
Stem Cell Secretome-Based Recombinant Protein Therapy for Treatment of Acute Kidney Injury
Principal Investigator: John Jackson, PhD; Co-PI Ji Hyun Kim, PhD, Wake Forest Institute for Regenerative Medicine
Biofabrication of Surface-functionalized, Thin Membranes for Vascularized Bone Tissue Engineering Repair of CMF Trauma
Principal Investigator: David Dean, PhD, The Ohio State University
Tissue Engineering Functional Human Lips
Principal Investigator: Stephen Feinberg, DDS, MS, PhD; Co-PI Mary-Ann Mycek, PhD, Regents of the University of Michigan
Nerve Regeneration and Muscle Integration: A Tissue Engineering Strategy to Accelerate Nerve Regeneration and Maximize Muscle Function Restoration
Principal Investigator: Anthony Windebank, MD, Mayo Clinic
Tension-based strategy for graft-free peripheral nerve reconstruction
Principal Investigator: Sameer Shah, PhD, University of California, San Diego
Targeting the Endotheliopathy of Trauma (EOT) with Lyophilized Mesenchymal Stem Cells (MSCs) and Lyophilized MSC Extracellular Vesicles (EVs)
Principal Investigator: Shibani Pati, MD, PhD, University of California San Francisco
Human Amnion Membrane Product (hAMP) for Treatment of Burn Wounds in Remote, Pre-hospital Setting
Principal Investigators: Shay Soker, PhD; Co-PI Sean Murphy, PhD, Wake Forest Institute for Regenerative Medicine
Acellular Muscle Fiber Fragment Platform for Rapid Recovery of Pelvic Floor Muscle Function
Principal Investigator: Ji Hyun Kim, PhD, Wake Forest Institute for Regenerative Medicine
Rapid Recovery of Rotator Cuff Muscle Function using Decellularized Muscle Fiber Fragments as an off-the-shelf Injection Therapy
Principal Investigator: James J. Yoo, MD, PhD, Wake Forest Institute for Regenerative Medicine
Reprogramming Subject Skin to Palmo-Plantar Skin at the Distal Limb to Enhance Prosthetic use in Wounded Warriors
Principal Investigator: Luis Garza, MD, PhD, Johns Hopkins University
Modular Lego-Like Scaffolds for In-theater Craniofacial Regeneration
Principal Investigator: Luiz Bertassoni, PhD, Oregon Health & Science University
Proof of Concept Clinical Trial of Burns: Inhibiting Scar Formation and Promoting Skin Regeneration using a Topical Focal Adhesion Kinase Inhibitor (FAKI)
Principal Investigator: Geoffrey Gurtner, MD, University of Arizona
Clinical Therapies
The team will focus on developing clinical therapies over the next 5 years in the areas of:
Craniofacial Regeneration
Extremity Regeneration
Genitourinary/ Lower Abdomen
Skin and Wound Healing
On-Demand Blood
