PRINCIPAL INVESTIGATOR: Luiz Bertassoni, D.D.S., Ph.D.
PERFORMING ORGANIZATION: Oregon Health & Science University
Recent advancements in 3D printing have revolutionized the field of tissue engineering, particularly in the creation of tailored scaffolds for tissue regeneration. However, widespread adoption of this technology in medical settings, especially in combat zones, remains impractical due to logistical challenges. In this project, our team proposes to address this gap with a novel scaffold assembly system utilizing prefabricated beta-tricalcium phosphate (β-TCP) modules, designed akin to LEGO blocks.
These modular scaffolds retain the precision and customization benefits of 3D printing, such as defect-specific geometries, while eliminating the need for specialized equipment and personnel on-site. They are designed to be intuitive, scalable for various complex shapes, and can be pre-packaged for sterile deployment. This innovation aims to facilitate efficient deployment in challenging environments such as combat zones, where immediate and precise medical interventions are critical.
Our research focuses on optimizing these LEGO-like scaffolds for craniofacial bone regeneration, particularly in mandibular, maxillary, and zygomatic reconstructions. The anatomical complexity of craniofacial bones necessitates scaffolds that can adapt to both straight and curved contours. Using FDA-approved β-TCP, our modular design allows for assembly into configurations that mimic the intricate shapes required for effective bone regeneration.
Preliminary studies in small animal models have demonstrated promising outcomes. LEGO-like scaffolds loaded with hydrogels showed excellent cell infiltration and vascularization compared to conventional scaffold blocks. These findings underscore the potential of our approach to accelerate healing processes in large critical-size defects, potentially reducing recovery times for patients.
Since funding of this award, we have been working with third party manufacturers to design and optimize the fabrication of the proposed LEGO-like beta-TCP scaffolds. Moving forward, our research will progress to large animal studies, specifically mini-pigs, to further validate the efficacy and safety of our modular scaffolds. Successful outcomes in these models will pave the way for FDA submission and subsequent clinical translation. Additionally, we are developing an Artificial Intelligence (AI)-assisted surgeon interface to enhance the ease and precision of scaffold assembly in clinical settings.
In conclusion, our project aims to deliver an innovative, deployable regenerative solution tailored for craniofacial bone injuries in military hospitals at combat zones. By combining modular design principles with advanced biomaterials and AI technology, we envision a future where complex bone reconstructions can be effectively managed even in resource-limited environments.