Burn injuries are among the most devastating of all injuries and a major global public health burden. Severe (full- and deep partial-thickness) burns are a significant challenge among military service members, often leading to debilitating hypertrophic scar (HTS) formation and scar contractures that severely compromise normal function. The current standard-of-care for severe burn wounds is the spit thickness skin grafts (STSG), which provides wound coverage. However, skin grafts often still result in scar contractures and other disadvantages including fragility, abnormal pigmentation, rough texture.