Proposal Solicitation

Program Announcement for the Armed Forces Institute of Regenerative Medicine (AFIRM)
Fiscal Year 2025 (FY25)
Advancing Therapeutic Reprogramming for Military Regenerative Medicine

Announcement Type: Initial
Funding Opportunity Number: AFIRM 002
Solicitation release by the Wake Forest Institute for Regenerative Medicine
The AFIRM Coordinating Center

URGENT NOTICE:  Now that the Government has reopened, the new Submission Deadline is Wednesday, November 26, 2025, Noon US Eastern Standard Time Zone.


The FY25 AFIRM Focus Areas are listed in below:

  • Focus Area #1: Craniomaxillofacial Regeneration
  • Focus Area #2: Extremity Regeneration                               
  • Focus Area #3: Genitourinary/lower abdomen Reconstruction        
  • Focus Area #4: Skin Regeneration
  • Focus Area #5: Ex-vivo/on demand Blood   
  • Focus Area #6: Cellular therapies for Trauma and Critical Care

NOTE: If you are including a clinical trial in your proposal, you must upload the Clinical Trial Study/Timeline Schedule in Attachment 2. If you are not including a clinical trial, upload a document stating that the study timeline is not applicable. A document must be uploaded in Attachment 2 for your proposal submission to be complete.

Submission and Review Dates

Request Issue Date: August 18, 2025

URGENT NOTICE:  Now that the Government has reopened, the new Submission Deadline is Wednesday, November 26, 2025, Noon US Eastern Standard Time Zone.


Peer Review: November 2025
Programmatic Review: December 2025
Award Negotiations Begin: February 2026