Principal Investigator: Susan M. Shea, PhD; Co-PI Matthew D. Neal, MDOrganization: University of Pittsburgh Combat-associated traumatic hemorrhage is implicated in approximately 90% of preventable deaths in the prehospital phase of resuscitation in the military, and traumatic brain injury (TBI) is a leading cause of death and coagulopathy. Promptly restoring hemostasis via correction of trauma-induced coagulopathy […]
Category: abstracts
Bioengineered Functional Craniomaxillofacial Alveolar Bone and Tooth Constructs
Principal Investigator: Pamela C. Yelick, PhDOrganization: Tufts University Craniomaxillofacial (CMF) injuries represented 33% of the battlefield injuries sustained in Operation Iraqi Freedom/Operation Enduring Freedom (Afghanistan)1, and 25% of wounded British and US soldiers who reached a medical Treatment facility 2. CMF battlefield injuries include 27% involving fracture, of which 36% were in the mandible and […]
Stem Cell Secretome-Based Recombinant Protein Therapy for Treatment of Acute Kidney Injury
Principal Investigator: John D. Jackson, PhD; Co-PI Ji Hyun Kim, PhDOrganization: Wake Forest Institute for Regenerative Medicine Acute kidney injury (AKI) is seen at a significantly high incidence in critically injured patients and is associated with increased mortality. In Iraq and Afghanistan wars, for instance, the rate of AKI in soldiers treated in the intensive […]
Biofabrication of Surface-functionalized, Thin Membranes for Vascularized Bone Tissue Engineering Repair of CMF Trauma
Principal Investigator: David Dean, PhDOrganization: The Ohio State University Craniomaxillofacial (CMF) trauma may result in a gap in the bones making up the braincase or the face. These are among the most common skeletal deficits suffered by trauma patients. Indeed, facial fractures, make up about 10% of civilian emergency room trauma, whereas CMF trauma made […]
Tissue Engineering Functional Human Lips
Principal Investigator: Stephen E. Feinberg, DDS, MS, PhD; Co-PI Mary-Ann Mycek, PhDOrganization: Regents of the University of Michigan Our novel approach to reconstruct composite lip defects utilizes a prelaminated microvascular free flap based on latissimus dorsi muscle (LDM). The laminate is a tissue engineered medical product (TEMP) that is composed of autogenous oral and skin […]
Nerve Regeneration and Muscle Integration: A Tissue Engineering Strategy to Accelerate Nerve Regeneration and Maximize Muscle Function Restoration
Principal Investigator: Anthony J. Windebank, MDOrganization: Mayo Clinic Americans incur over 300,000 nerve injuries annually. Nerve injury leads to lost of limb function and oftentimes is accompanied by neuropathic pain. It causes significant personal hardship and socioeconomic burdens. In wounded warriors, 37% have nerve involvement in limb injury. Disability following nerve injury accounted for over […]
Tension-based strategy for graft-free peripheral nerve reconstruction
Principal Investigator: Sameer B. Shah, PhDPerforming Organization: University of California, San Diego Vehicular trauma and blast injuries are common causes of damage to the extremities of military personnel, often resulting in severe injury to peripheral nerves. Nerve injury results in motor impairment, sensory loss, and pain; beyond sensorimotor deficits, individuals experience feelings of frustration and […]
Targeting the Endotheliopathy of Trauma (EOT) with Lyophilized Mesenchymal Stem Cells (MSCs) and Lyophilized MSC Extracellular Vesicles (EVs)
Principal Investigator: Shibani Pati, MD, PhDOrganization: University of California San Francisco The main goal of this project is to develop and test dried stem cell products (lyophilized-MSCs and lyophilized-MSC EVs) for their potential to attenuate the Endotheliopathy of Trauma and mitigate outcomes in severely injured patients in need of pre-hospital care. The rationale for the […]
Human Amnion Membrane Product (hAMP) for Treatment of Burn Wounds in Remote, Pre-hospital Setting
Principal Investigators: Shay Soker, PhD; Co-PI Sean Murphy, PhDOrganization: Wake Forest University Health Sciences Given the unpredictable future battle and casualty management environment, with definitive burn treatment occurring only post-evacuation, there is a need for effective and comprehensive trauma wound treatment capabilities deployable prehospital. Biological products such as amnion membrane shown efficacy in accelerating wound […]
Acellular Muscle Fiber Fragment Platform for Rapid Recovery of Pelvic Floor Muscle Function
Principal Investigator: Ji Hyun Kim, PhDOrganization: Wake Forest Institute for Regenerative Medicine Pelvic and urogenital injuries account for 86% of urologic injuries in US armed conflicts, impacting the medical and combat readiness of wounded soldiers. Current surgical repair attempts often fail in restoring normal pelvic muscle anatomy. While autologous cell-based treatment shows promise in improving […]